Cisplatin side-effects

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August undefined, 2024

WebCisplatin remains a major antineoplastic drug for the treatment of solid tumors. Its chief dose-limiting side effect is nephrotoxicity, which evolves slowly and predictably after initial and repeated exposure. The kidney accumulates cisplatin to a higher degree than other organs perhaps via mediated ….

Nephrotoxicity as a Dose-Limiting Factor in a High-Dose Cisplatin …

WebApr 13, 2024 · Testicular cancer, also known as testicular germ cell tumors (TGCT), is the most common type of cancer in young men. When treated with cisplatin, the tumor cells stop growing and die. This is because the cytostatic drug causes damage to DNA, the carrier of genetic information, thus stopping the cell cycle. WebMay 15, 2024 · Other common side effects include anaphylaxis, cytopenias (including leukopenia and neutropenia, thrombocytopenia, and anaemia), hepatotoxicity, ototoxicity, cardiotoxicity, nausea and vomiting, diarrhea, mucositis, stomatitis, pain, alopecia, anorexia, cachexia, and asthenia. c.s. retro series tl

Cisplatin nephrotoxicity - UpToDate

WebCommon side effects of cisplatin Risk of infection This treatment can reduce the number of white blood cells in your blood. These cells fight infection. If the number of white blood cells is low, you are more likely to get an infection. A low white blood cell count is sometimes called neutropenia. Serious side effects of Cisplatin. Black, tarry stools. blood in urine or stools. burning, numbness, tingling, or painful sensations. change in frequency of urination or amount of urine. cough or hoarseness. difficulty in breathing. dizziness. drowsiness. feeling of fullness in the ears. fever or ... See more Commonly reported side effectsof cisplatin include: bone marrow depression, nephrotoxicity, and ototoxicity. Continue reading for a comprehensive list of adverse effects. … See more Some side effects of cisplatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your … See more Along with its needed effects, cisplatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediatelyif any of … See more Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Some side effects may not be reported. You … See more WebThese side effects can include: Hair loss Mouth sores Loss of appetite Nausea and vomiting Diarrhea Increased chance of infections (from having too few white blood cells) Easy bruising or bleeding (from having too few blood platelets) Fatigue (extreme tiredness, often from having too few red blood cells) cs resume example reddit

Molecules Free Full-Text The Challenging Treatment of Cisplatin ...

DAY 2 AFTER CISPLATIN TREATMENT - HOW SHOULD I FEEL???

WebWhen DNA is cross-linked in this manner, the cell undergoes apoptosis, or systemic cell death. Damage to the DNA activates the cell's repair mechanisms. Once the repair mechanisms are activated and the cells are found to not be salvageable, the death of those cells is triggered instead. WebIncreased risk of getting an infection is due to a drop in white blood cells. Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. You might have other symptoms depending on where the infection is. Infections can sometimes be life threatening. cs resume maker freeWebCisplatin (10 mg) side effects All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Diarrhea; loss of appetite; nausea; vomiting; weakness. Seek medical attention right away if any of these SEVERE side effects occur: ea online class

"WebCommon side effects of chemo include: Nausea and vomiting Loss of appetite Hair loss Mouth sores Diarrhea Constipation Increased risk of infections (because of a shortage of white blood cells) Easy bleeding or bruising, even after minor cuts or injuries (due to a shortage of blood platelets) Fatigue (because of a shortage of red blood cells) " - Cisplatin side-effects

Cisplatin side-effects

WebDec 12, 2024 · Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Hair loss. Diarrhea, throwing up, upset stomach, and decreased appetite are common with this drug. If these happen, talk with your doctor about ways to lower these side effects. WebExposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well as injury to the renal vasculature, results in vasoconstriction, reduced blood flow, and ischemic injury. Collectively, these changes lead to acute kidney injury (AKI) [ 4 ].

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WebCisplatin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: nausea; vomiting; diarrhea; hair loss; loss in ability to taste food; hiccups; dry mouth, dark urine, decreased sweating, dry skin, and other signs of dehydration; Some side effects can be serious. WebSep 15, 2024 · Common side effects of Cisplatin include: nausea and vomiting (may be severe), diarrhea, temporary hair loss, loss in ability to taste food, hiccups, dry mouth, dark urine, decreased sweating, dry skin, and other signs of dehydration. Dosage for Cisplatin? Dosage of cisplatin depends on the type of cancer being treated.

WebFeb 16, 2016 · However, a high-dose cisplatin regimen is associated with major toxic side effects (myelosuppression, neurotoxicity, ototoxicity, and nephrotoxicity). In cisplatin-based CCRT schedules, acute nephrotoxicity is commonly graded by an increase of serum creatinine levels, according to the Common Terminology Criteria for Adverse Events … WebSome common side effects include: Hair loss Mouth sores Loss of appetite or weight changes Nausea and vomiting Diarrhea or constipation Chemo can also affect the blood-forming cells of the bone marrow, which can lead to: Increased chance of infections (from low white blood cell counts) Easy bruising or bleeding (from low blood platelet counts)

WebFeb 1, 2024 · blistering, peeling, or loosening of the skin blue-yellow color blindness dark urine decreased vision eye pain joint or muscle pain loss of appetite nausea or vomiting red, irritated eyes red skin lesions, often with a purple center seizures yellow eyes or skin Some side effects may occur that usually do not need medical attention. Weboptic disk edema. sudden blindness and pain upon moving the eye. blindness due to damage in the brain. a heart attack. a clot in the lung. fluid in the covering of the heart or pericardium ...

WebOct 7, 2024 · 3. Cisplatin Nephrotoxicity. Experimental nephrotoxicity, first reported in 1971 [], is the most frequently studied cisplatin side effect.Over the past decades, researchers have demonstrated that cisplatin can cause nephrotoxicity or acute kidney injury (AKI) of varying severity in a dose-dependent manner [].Depending on the dose (single or …

WebFeb 1, 2024 · pains in the stomach, side, or abdomen, possibly radiating to the back pale skin sweating unusual tiredness or weakness weight loss yellow eyes or skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. csret hdmi switch with pipWebSep 18, 2024 · Uric acid-reducing treatments may be necessary. [25][27] Common Side Effects[27] Mild nausea Vomiting Diarrhea Temporary hair loss Loss in the ability to taste food Hiccups Dry mouth Dark urine … eaon mall uchiharaWebFeb 1, 2024 · nosebleeds. pain or discomfort in the arms, jaw, back or neck. pains in the stomach, side, or abdomen, possibly radiating to the back. pale skin. sweating. unusual tiredness or weakness. weight loss. yellow eyes or skin. Some side effects may occur that usually do not need medical attention. ea onr mouWebSep 15, 2024 · SIDE EFFECTS. Nephrotoxicity - Dose-related and cumulative renal insufficiency is the major dose-limiting toxicity of cis-platin. Renal toxicity has been noted in 28% to 36% of patients treated with a single dose of 50 mg/m 2.It is first noted during the second week after a dose and is manifested by elevations in BUN and creatinine, serum … ea online serversWeba condition that causes blood clots to form in the small blood vessels in the kidneys (haemolytic uraemic syndrome), this leads to low red blood cells (anaemia), kidney failure and low levels of platelets. a second cancer called acute leukaemia. low levels of magnesium in your blood. ea on teams profileWebOct 5, 2014 · Relative to cisplatin, the greatest benefit of carboplatin is its reduced side effects, particularly the elimination of nephrotoxic effects. The main drawback of carboplatin is its myelo suppressive effect which causes the blood cell and platelet output of bone marrow in the body to decrease quite dramatically, sometimes as low as 10% of its ... ea online playWebThe major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, electrolyte abnormalities, myelosuppression, ototoxicity, peripheral neuropathy, hepatotoxicity and retinopathy. Diarrhoea, pancreatitis, seizures and respiratory failure have also been reported. No specific antidote for cisplatin exists. csre uk approach linkedin feb11