High theophylline levels
WebJun 20, 2024 · High blood sugar (increased thirst, increased urination, hunger, dry mouth, drowsiness, blurred vision, weight loss) ... Low levels of theophylline and caffeine may indicate that the drug has not reached a therapeutic level for the individual tested and there is insufficient drug present to be effective. WebFeb 26, 2013 · Theophylline increases histone deacetylase-2 (HDAC2) via inhibition of phosphoinositide-3-kinase-δ (PI3Kδ), which is activated by oxidative stress to phosphorylate and reduce HDAC2. HDAC2 deacetylates core histones that have been acetylated by the histone acetyltransferase (HAT) activity of coactivators, such as CREB-binding protein …
High theophylline levels
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WebFeb 10, 2024 · The reference therapeutic ranges of theophylline are listed below. Reference ranges of theophylline in the treatment asthma vary by age, as follows: Adults: 5-15 µg/mL. Children: 5-10 µg/mL. The... The assessment and diagnosis of exercise-induced bronchoconstriction is made … WebSymptoms usually manifest if serum theophylline level 20-25 mg/L 1, 2. Symptoms increase in frequency and severity with increasing levels (significant individual variability exists …
WebTherapeutic levels: 4 to 12 mcg/ml [SI: 17 to 51 micromole/L] Note: 4 to 8 mcg/mL if patient is receiving other anticonvulsants. Half-life: 8 - 60 hours in adults Epoxide metabolite: 25 to 43 hours (active metabolite) Time to … WebAug 31, 2024 · high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor. Serious side effects may be more likely in older adults. Common side effects …
WebAug 31, 2024 · High-risk cases include the following: Acute overdose with theophylline levels higher than 80 mcg/mL Chronic toxicity with levels higher than 40 mcg/mL Patients … WebSafe levels for people taking theophylline are often 8 to 20 mcg/mL. Levels above 20 mcg/mL may be harmful and can happen if people take too many pills within a short time period. Such cases might include accidentally taking extra pills or having a prescription that was written for too high a dose.
WebPurpose: To evaluate prospectively whether serum theophylline concentrations of 25 mg/L and greater were predictable (and presumably preventable) by use of basic pharmacokinetic calculations. Design: Prospective study. Patients: Fifty-five patients with a serum theophylline concentration of at least 25.0 mg/L were evaluated initially and if subsequent …
WebToxic side effects of elevated theophylline levels range from minor symptoms to life-threatening complications. We investigated the incidence of life-threatening events in … compliance soberlink.comWebTheophylline levels In most individuals a plasma theophylline of between 10-20mg/litre is required for satisfactory bronchodilation; however, a lower plasma theophylline … compliances in hrWebMar 22, 2024 · Theophylline: Although causality has not been established, concurrent use of pentoxifylline with theophylline has resulted in elevated theophylline plasma levels, which may enhance the possibility of adverse effects. Drug-Food Interactions. Interactions with food have not been established. Drug-Herb Interactions eccrine cystadenoma pathologyWebJul 18, 2024 · In high doses, theophylline can cause irritability, tremors and seizures as well as tachycardia, cardiac arrhythmias and sudden death. With the development of safer, better tolerated and more effective inhaled … compliances of gstWebOct 4, 2024 · In patients with theophylline overdose who are at high risk for theophylline-induced seizures, e.g., patients with acute overdoses and serum theophylline concentrations > 100 mcg/mL or chronic overdosage in patients > 60 years of age with serum theophylline concentrations > 30 mcg/mL, the need for anticonvulsant therapy should be anticipated ... compliances in healthcareWebJul 26, 2024 · Too high: 20 to 25 µg/mL: Decrease doses by about 10% and recheck serum level after 3 days. 25 to 30 pg/mL: ... Serum levels should be monitored periodically to determine the theophylline level associated with observed clinical response and to identify the potential for toxicity. For such measurements, the serum sample should be obtained … compliances of fpoWebSixty patients with theophylline toxicity were hospitalized during a 2-year period. Eleven patients had hypercalcemia; their calcium levels returned to normal as theophylline levels … compliances newsletter