Incidence of rhabdomyolysis with daptomycin

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August undefined, 2024

WebRhabdomyolysis is a known possible complication associated with daptomycin therapy. However, previous findings were predominantly in phase 1 and 2 trials, and the effects … WebMar 7, 2024 · Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp [ 1,2 ].

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WebThe incidence of myopathy and rhabdomyolysis were highest during the first year and then decreased during the subsequent years of treatment. ... Daptomycin Clinical Impact: Cases of rhabdomyolysis have been reported with simvastatin administered with daptomycin. Both simvastatin and daptomycin can cause myopathy and rhabdomyolysis when given ... WebEarly-onset rhabdomyolysis related to daptomycin use. Early-onset rhabdomyolysis related to daptomycin use Int J Antimicrob Agents. 2007 Nov;30(5):472-4. doi: … birmingham airport minibus taxi

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WebDaptomycin is reported to cause an elevation in creatine kinase levels, although frank rhabdomyolysis is rare. An even more infrequent occurrence is the simultaneous development of acute kidney injury and drug-induced liver injury with rhabdomyolysis. Daptomycin and rifampin combination are used for synergistic bactericidal action against … WebJan 16, 2024 · Rhabdomyolysis means dissolution of skeletal muscle, and it is characterized by leakage of muscle cell contents, myoglobin, sarcoplasmic proteins (creatine kinase, lactate dehydrogenase, aldolase, … WebSep 29, 2024 · Introduction. Daptomycin is a lipopeptide antibiotic often used for the treatment of methicillin-resistant Staphylococcus aureus (MRSA). Despite its clinical utility, there have been a few reports of rhabdomyolysis related to daptomycin use [1,2].In this report, we present a case of rhabdomyolysis, severe hyperkalemia, and acute kidney injury … dan crenshaw gop

Safety outcomes with high‐dose daptomycin in patients with …

Statin use increases risk of daptomycin-related rhabdomyolysis

WebDaptomycin has been associated with raised creatine kinase activity, with a reported incidence of 2.8% in phase III clinical trials (167 A). Rhabdomyolysis has also been described (168 A ) . A 45-year-old woman with refractory acute myeloid leukemia was given intravenous daptomycin 550 mg (6 mg/kg) every 24 hours because of bacteremia due to ... WebJan 1, 2024 · There was no other potential source of rhabdomyolysis in this patient and this is the first case report documenting concomitant renal injury as well as DILI secondary to daptomycin administration. Another case reported in 2007 similarly found elevations in CK as well as transaminase levels with significant muscle weakness after daptomycin ... birmingham airport luggage wrappingWebDec 4, 2024 · Daptomycin is available in generic forms and under the brand name Cubicin in single use vials of 500 mg. The typical dose is 4 to 6 mg/kg once daily for 7 to 28 days, depending upon the type of infection and … dan crenshaw it\u0027s time for conservatives

"WebDec 13, 2024 · The incidence of rhabdomyolysis was significantly higher following concomitant daptomycin and statin use than with daptomycin alone (OR = 11.60, 95% CI … " - Incidence of rhabdomyolysis with daptomycin

Incidence of rhabdomyolysis with daptomycin

(PDF) Rhabdomyolysis during Therapy with Daptomycin

Webof daptomycin use. Rhabdomyolysis is more commonly seen in a dose-dependent manner, especially at higher doses of daptomycin (8 mg/kg/day) compared to standard doses (6 mg/kg/day) [3]. Here, we described a case of recurrent hyperkalemia when daptomycin was initiated and completely resolved once daptomycin was discontinued. WebDaptomycin, a cyclic lipopeptide antibiotic, has bactericidal activity against Gram-positive organisms ... Although daptomycin causes unique adverse drug reactions such as elevation of creatine phosphokinase or rhabdomyolysis, the detailed ... and incidence of CPK elevation. Second, an in vitro pharmacological study was conducted using cul-

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WebApr 16, 2024 · Background: Daptomycin-associated myopathy has been identified in 2-14% of patients, and rhabdomyolysis is a known adverse effect. Although risk factors for daptomycin-associated myopathy are... WebNov 23, 2024 · Citation 8 In contrast, a study by Graham et al Citation 9 in 2004 reported an average incidence of 0.44 in 10,000 patients (who developed rhabdomyolysis) being treated with atorvastatin, simvastatin, or pravastatin, with a 95% confidence interval of 0.20–0.84. These patients had been taking lipid-lowering agents alone or in combination.

WebRhabdomyolysis has been reported in up to 5 percent of treated patients receiving daptomycin . Factors conferring increased risk for daptomycin-associated myopathy or rhabdomyolysis include : … Overview of the causes and treatment of hyperphosphatemia … WebNov 17, 2024 · However, the risk of developing rhabdomyolysis from statin therapy is very low, around 1.5 for each 100,000 people taking statins. Rhabdomyolysis or milder forms …

WebJun 15, 2006 · Abstract. The use of daptomycin has been associated with an elevation in creatine phosphokinase level, with a reported incidence of 2.8% in phase III clinical trials. … WebRhabdomyolysis is a well-known clinical syndrome of muscle injury associated with myoglobinuria, electrolyte abnormalities, and often acute kidney injury (AKI). The pathophysiology involves injury to the myocyte membrane and/or altered energy production that results in increased intracellular calcium concentrations and initiation of destructive …

WebOct 5, 2024 · The primary outcome was overall incidence of creatine phosphokinase (CK) elevation, myopathy and rhabdomyolysis. Results and discussion A total of 74 patients who received daptomycin therapy were screened with 50 included in the study.

WebConclusion: Daptomycin can be associated with elevations in CPK level and rhabdomyolysis despite reduction of dose. A baseline CPK level before starting … dan crenshaw election results 2022WebJul 1, 2006 · The use of daptomycin has been associated with an elevation in creatine phosphokinase level, with a reported incidence of 2.8% in phase III clinical trials. birmingham airport meet and greet parkingWebDec 11, 2024 · Daptomycin is associated with an increased incidence of myopathy and rhabdomyolysis. There have been cases reported in patients with and without acute renal … birmingham airport official car parkingWebMar 19, 2024 · The meta-analysis found that statin use significantly increased the incidence of DAP-related rhabdomyolysis compared with no statin use (6.2% vs 13.0%; odds ratio [OR] 3.83; 95% CI 1.43, 10.26) but had no significant effect on the incidence of DAP-related myopathy (6.6% vs 6.0%). birmingham airport no 1 loungeWebDaptomycin is associated with a number of adverse effects including eosinophilic pneumonia, hypersensitivity reaction, myopathy, rhabdomyolysis, headache and … dan crenshaw facebook pageWebDec 4, 2024 · National Center for Biotechnology Information dan crenshaw homeland security committeeWebFactors conferring increased risk for daptomycin-associated myopathy or rhabdomyolysis include : … Overview of the causes and treatment of hyperphosphatemia … lysis syndrome, muscle necrosis ( rhabdomyolysis ), and, rarely, marked hemolysis or … dan crenshaw internship