Web6 Jul 2012 · Kynurenine aminotransferase from Pyrococcus horikoshii OT3 (PhKAT), which is a homodimeric protein, catalyzes the conversion of kynurenine (KYN) to kynurenic acid (KYNA). We analyzed the transaminase reaction mechanisms of this protein with pyridoxal-5′-phosphate (PLP), KYN and α-ketoglutaric acid (2OG) or oxaloacetic acid … Web14 Jun 2024 · On the other hand, KYNA is a broad-spectrum competitive antagonist of glutamate (Glu) receptors. KYNA antagonizes intestinal N-methyl-D-aspartate (NMDA) receptors, a type of Glu receptor. KYNA regulates oxidative and nitrosative stress pathways and reduces the production of inflammatory factors [ 95 ].
Characteristic Features of Kynurenine Aminotransferase ... - PLOS
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