P53 research
WebJan 1, 2005 · The discovery of p53 in 1979 marks the beginning of a most fascinating era of modern cancer research and molecular biology, an era that is still in full swing and does not show any signs of... WebJul 16, 2024 · The p53 protein, made by the TP53 gene, normally acts as the supervisor in the cell as the body tries to repair damaged DNA. Different mutations can determine how well or how poorly that supervisor is able to direct the response. The more defective the mutation, the greater the risk.
P53 research
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WebMar 30, 2024 · The wild-type p53 protein is a transcriptional activator implicated in the control of cellular growth-related gene expression. Here, using a number of different cell lines and transient-transfection–transcription assays, we demonstrate that at low levels, wild-type p53 transactivates the human proliferating cell nuclear antigen (PCNA) promoter. WebDec 9, 2024 · The p53 gene codes a protein necessary for normal cell function. 2 Many cancers, including mesothelioma, have a mutation in the p53 gene. 3 Gene therapy restores p53 to its normal function and helps stop cancer cell growth. 4 Like other emerging treatments, p53 gene therapy is only available in clinical trials.
WebApr 1, 2024 · p53 plays a key role in tumor suppression. The tumor suppressive function of p53 has long been attributed to its ability to induce apoptosis, cell cycle arrest, and … Webp53 is the protein encoded by the TP53 tumor suppressor gene. p53, referred to as the “guardian of the genome,” plays an essential role in cancer prevention. The loss of proper …
WebDec 2, 2024 · The transcription factor p53 regulates a host of cellular responses to damage and distress ( Kruiswijk et al., 2015 ). Its abilities to halt cell cycle progression, upregulate DNA repair pathways, and induce apoptosis help prevent deleterious mutations from propagating in cell populations. Webp53 is among the most critical tumor suppressor genes and is the most extensively studied gene in tumor biology within the past 40 years [1]. Due to its multiple functions in tumor, …
WebThe TP53 Database is meant to be a source of information on TP53 variants for a broad range of scientists and clinicians who work in different research areas:. Basic research, to study the structural and functional aspects of the p53 protein and the TP53 gene; Molecular pathology of cancer, to understand the clinical significance of TP53 variants identified in …
WebFeb 1, 2024 · It turns out that the DDR factor p53 takes center stage during tumor development and also plays an important role in the aging process. ... SFB 670, and KFO 286) (B.S.), a starting grant from the European Research Council (ERC 260383), Marie Curie Initial Training Network (FP7 ITN CodeAge 316354, aDDRess 316390, MARRIAGE … red eyes medicalWebp53 is among the most critical tumor suppressor genes and is the most extensively studied gene in tumor biology within the past 40 years [1]. Due to its multiple functions in tumor, p53 has been recognized as a promising target to treat cancer [2]. In order to leverage the crucial roles of p53 in tumor therapy, it is necessary to illuminate the exact mechanisms for p53 … red eyes medical conditionWebAug 11, 2024 · In this Research Topic, a few excellent reviews summarize the latest achievements in this field. (1) Zhu et al. outline the spectrum of tumorigenic activities displayed by mutant p53 and discuss different therapeutic strategies to target cancer with TP53 mutations. The key targeted approaches -small molecule reactivators, gene editing, … knock rap crossword clueWebApr 14, 2024 · Abstract. Mutations that occur within the oligomerization domain (OD) of the tumor suppressor p53 generally abolish p53 tetramerization and are associated with increased cancer susceptibility in Li-Fraumeni syndrome (LFS). Despite their prevalence, the impact of OD-mutant p53 proteins in cancer, especially beyond a loss of canonical p53 … knock rd furnishingsWebOct 1, 2024 · Leading p53 researcher Hua Lu, PhD, of Tulane University School of Medicine, was chosen to edit a special edition of a medical journal dedicated to the history of p53 … knock recastWebMar 21, 2024 · TP53 (Tumor Protein P53) is a Protein Coding gene. Diseases associated with TP53 include Li-Fraumeni Syndrome and Papilloma Of Choroid Plexus . Among its related pathways are MyD88 dependent cascade initiated on endosome and Regulation of activated PAK-2p34 by proteasome mediated degradation . Gene Ontology (GO) … knock religious goodsWebNational Center for Biotechnology Information red eyes medicine