Phenytoin purple glove syndrome
WebApr 8, 2024 · An uncommon but serious adverse drug reaction after phenytoin administration is known as purple glove syndrome (PGS). Initial presentation is characterized by pain, skin discoloration, and edema, that can progress to necrosis. The pathophysiology remains uncertain; however, multiple mechanisms have been reported … WebPA-PSRS has received several reports regarding “purple glove syndrome,” an adverse drug reaction related to intravenous administration of phenytoin (DILANTIN). To address this …
Phenytoin purple glove syndrome
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WebJan 13, 2014 · Phenytoin is the prototypical basic drug that causes a clinical manifestation known as purple glove syndrome (PGS). This syndrome is largely managed through preventive and conservative treatment measures. Promethazine is acidic and can cause a devastating extravasation, particularly if administered inadvertently through the arteriolar … WebPurple glove syndrome is a progressive distal limb edema, associated with discoloration and pain and is most likely due to the extravasation of the highly basic IV phenytoin solution. Local cutaneous reactions include signs and symptoms of PGS …
WebPurple glove syndrome following intravenous phenytoin administration N J Prince, C Hill Correspondence to Dr N J Prince, Children's Critical Care Centre, Kings College Hospital, Denmark Hill, London SE5 9RS, UK; …
Webpurple glove syndrome: A condition resulting from IV injection of phenytoin, in which there is discolouration, oedema and blister formation of the hand—or acral parts distal to an IV injection site; the oedema evoked may cause ischaemic necrosis, necessitating amputation WebSep 1, 2024 · Purple glove syndrome (PGS) is an atypical adverse drug reaction that can occur after the administration of intravenous phenytoin. Although definitions of PGS vary, it has been loosely defined as signs and symptoms of progressive edema, discoloration, and pain that occurs following administration of intravenous phenytoin [1].
Purple glove syndrome (PGS) is a poorly understood skin disease in which the extremities become swollen, discoloured and painful. PGS is potentially serious, and may require amputation. PGS is most common among elderly patients and those receiving multiple large intravenous doses of the epilepsy drug phenytoin. Compartment syndrome is a complication of PGS.
WebPurple Glove Syndrome Treatment As it is the complication of phenytoin so physician recommends to quit the use of phenytoin. Reducing or quiting the intake of phenytoin helps a lot in controlling purple glove syndrome. Other than this, heat packs are applied on the skin to relief pain. Other than intravenous phenytoin, oral phenytoin may also ... outward bound zimbabweWebApr 1, 2016 · Though the impact of phenytoin on warfarin has been reported to potentiate the anticoagulant effect or interact in a biphasic manner, the effect of phenytoin on warfarin appears to be... outward bound wilderness therapyWebJan 15, 2024 · “Purple Glove syndrome” is a rare side effect that can occur with intravenous administration of phenytoin. It is characterized by worsening distal limb edema and discoloration which can lead to extensive skin necrosis and limb ischemia. outward bound wilderness coursesWebSep 1, 2024 · Purple glove syndrome (PGS) is an atypical adverse drug reaction that can occur after the administration of intravenous phenytoin. Although definitions of PGS vary, it has been loosely defined as signs and symptoms of progressive edema, discoloration, and pain that occurs following administration of intravenous phenytoin [1]. raising the village jobs 2021WebPurple glove syndrome following intravenous phenytoin administration N J Prince, C Hill Correspondence to Dr N J Prince, Children's Critical Care Centre, Kings College Hospital, Denmark Hill, London SE5 9RS, UK; … raising the titanicWebPhenytoin also precipitates in any glucose-containing solution, such as D 5 W. The diluent causes the phenytoin solution to be inflammatory and painful when there is extravasation from an IV. Tissue necrosis can occur with extravasation. In its extreme form, the phenytoin extravasation may result in the formation of the purple glove syndrome. outward bound worthingWebSep 1, 2024 · Purple glove syndrome (PGS) is an atypical adverse drug reaction that can occur after the administration of intravenous phenytoin. Although definitions of PGS vary, … outward bound wisconsin